HIV-1 infection and antibodies to Plasmodium alciparum in adults

Abstract

Background. Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally acquired immunity. Methods. In 339 adults (64% HIV infected), we measured antibodies to Plasmodium falciparum variant surface antigens (VSA) and antibodies that opsonise infected erythrocytes using parasite lines FCR3, E8B, and R29, and antibodies to merozoite antigens AMA-1 and MSP2. We determined the relationship between malaria antibodies, HIV infection, markers of immune compromise, and risk of incident parasitemia. Results. HIV-infected adults had signi ficantly lower mean levels of opsonizing antibody to all parasite lines (P < .0001), and lower levels of ant..